352 HOW DOES PATIENT AGE REALLY EFFECT QUALITY OF LIFE OUTCOMES AFTER RADICAL PROSTATECTOMY FOR LOCALIZED PROSTATE CANCER?

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History (II)1 Apr 2013352 HOW DOES PATIENT AGE REALLY EFFECT QUALITY OF LIFE OUTCOMES AFTER RADICAL PROSTATECTOMY FOR LOCALIZED PROSTATE CANCER? Sanoj Punnen, Allison Glass, Janet Cowan, Matthew Cooperberg, and Peter Carroll Sanoj PunnenSanoj Punnen San Francisco, CA More articles by this author , Allison GlassAllison Glass San Francisco, CA More articles by this author , Janet CowanJanet Cowan San Francisco, CA More articles by this author , Matthew CooperbergMatthew Cooperberg San Francisco, CA More articles by this author , and Peter CarrollPeter Carroll San Francisco, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1738AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Previous studies have suggested that younger men do better with respect to sexual and urinary quality of life after surgery for prostate cancer. The objective of this study was to review urinary and sexual function and bother outcomes 2 years after radical prostatectomy and to see how these results differed by patient age at treatment. METHODS Men within the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) database were selected for this analysis if they had radical prostatectomy for localized prostate cancer and had quality of life data at baseline and 2 years post treatment. UCLA Prostate Cancer Index was used to provide a validated assessment of urinary and sexual function and bother at baseline and follow up. Repeated measures mixed model regression was used to assess the effect of age (characterized into <55, 56-65, and > 65 years) on urinary and sexual function and bother scores after surgery. Logistic regression was used to assess the effect of age on the likelihood of a significant decline in urinary and sexual function and bother scores, defined as a half standard deviation decline from baseline. RESULTS 2018 men made up the final analytic cohort. Age did not appear to have a significant effect on urinary function and bother scores over time. Figure 1 shows mean sexual function scores after adjustment for common demographic and clinical variables. Younger patients had higher scores after treatment, however they also had larger declines in sexual function scores after treatment compared to older patients. Sexual bother did not appear to differ significantly by age after surgery. Logistic regression showed that patients who were 56-65 years were less likely to undergo a significant decline in sexual function at 2 years after surgery compared to younger (<55 years) patients (OR 0.71, 95% CI 0.5-0.97, p=0.03) but there was no difference between patients who were <55 years and those who were >65 years (p=0.14). CONCLUSIONS Although younger patients have higher sexual function scores after surgery they have more to lose and may undergo larger declines then older patients. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e142-e143 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sanoj Punnen San Francisco, CA More articles by this author Allison Glass San Francisco, CA More articles by this author Janet Cowan San Francisco, CA More articles by this author Matthew Cooperberg San Francisco, CA More articles by this author Peter Carroll San Francisco, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...