(352) - Contemporary Survival and Outcomes Following Airway Dehiscence Post Lung Transplantation: A Significant Price to Pay

Abstract

Results: The oneand 5 year survival rates in Group 1 were significantly better than Group 2 (87% and 69% vs. 80% and 34%, respectively, p< 0.001, log rank test). In multivariate analysis, a ZRS consisting of ≥ 3 comorbidities and ZDS of ≥ 3 points were found to be significant risk factors for mortality in Group 2 (N= 14 HR 2.79; 95%CI 1.29-6.02 and N= 37 HR 2.30; 95%CI 1.31-4.04, respectively). In Group 1, ZRS of ≥ 3 was also found to be a risk factor for mortality using the same multivariate model (N= 21, HR 2.50; 95%CI 1.37-4.58). In Group 1, ZDS ≥ 3 was not found to be a risk factor. Conclusion: The accumulation of three ore more comorbidities was a risk factor for mortality in both young and old lung transplant recipients. The negative impact of extended donor lungs seems stronger in older recipients. In order to maximize posttransplant outcome, careful candidate selection and risk calculation weighing comorbidities is crucial.