351 The circular RNA circGLIS3 activates dermal fibroblasts and increases ECM production to improve wound healing

Abstract

Skin wound repair is a complex process that requires intricate coordination of different cell types to bring about healing. Delayed wound healing or excessive scarring are consequences of an impaired healing process and represent a major health and economic burden worldwide. Circular RNAs (circRNAs) are a family of transcripts with unique structures - the 3’ and 5’ ends are joined together through a process called back-splicing. CircRNAs were shown to be more stable and have tissue specific expression patterns and diverse modes of action.