Abstract
BackgroundTreatment with abiraterone acetate + prednisone can improve outcomes in mCRPC patients with or without prior chemotherapy. Cohort D of phase 1b/2 study KEYNOTE-365 (NCT02861573) evaluated safety and efficacy of...
Highlights
Treatment with abiraterone acetate + prednisone can improve outcomes in mCRPC patients with or without prior chemotherapy
Treatment-related AEs (TRAEs) were experienced by 90.3% of patients and most common (!15%) were ALT increase (22.3%), AST increase (17.5%), asthenia (16.5%), and diarrhea (16.5%); 36.9% experienced grade 3–5 TRAEs
Trial Registration ClinicalTrials.gov, identifier: NCT02861573 Ethics Approval The study and the protocol were approved by the Institutional Review Board or ethics committee at each site
Summary
Treatment with abiraterone acetate + prednisone can improve outcomes in mCRPC patients with or without prior chemotherapy. Cohort D of phase 1b/2 study KEYNOTE-365 (NCT02861573) evaluated safety and efficacy of PD-1 inhibitor pembrolizumab + abiraterone acetate and prednisone in patients who had not received chemotherapy for mCRPC
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