(351) - Interleukin 12-Dependent CMV-Specific CD4+ T Cell Proliferation, T-bet Induction and Effector Function During Primary Infection Are Key Determinants for Early Immune Control in Lung Transplant Recipients

Abstract

s S137 recipients) were divided into two groups, the flat chest (FC) group and the normal chest (NC) group. The thoracic shape was defined by the measurement of anteroposterior and transverse dimensions of the thorax. Pulmonary function was assessed perioperatively. Results: Twenty donor grafts were in the FC group and 12 were in the NC group. There were no significant differences in FVC size matching between the FC and NC groups (p= 0.94). In the FC group, postoperative FVC ratio to the preoperatively estimated FVC of the donor graft (FVCR post/pre) was 0.67 ± 0.24, 0.82 ± 0.39, and 0.86 ± 0.45, at 3 months, 6 months, and 1 year, respectively. In the NC group, FVCR post/pre was 0.99 ± 0.44, 1.03 ± 0.59, and 1.14 ± 0.42, at 3 months, 6 months, and 1 year, respectively. There was a significant difference in FVCR post/pre between the groups at 3 months after LDLLT (p= 0.01). This trend existed even 1 year after LDLLT between the groups (p= 0.08). Conclusion: Postoperative pulmonary function in a patient with flat chest was significantly worse in the early phase after bilateral LDLLT. Preoperative thoracic shape might be important for estimating the postoperative pulmonary function in lung transplantation.