Abstract
EUS guided intratumoral therapy is a promising development in the treatment of pancreatic cancer. Intratumoral vaccination is an emerging strategy for immunotherapy of tumors. Our laboratory was the first to demonstrate effective treatment of murine solid tumor models with intratumoral poxvirus vaccine. The recombinant pox viral vaccine “Panvac” encodes tumor antigens CEA and Muc-1 and 3 immune co-stimulatory antigens B7, LFA-3 and ICAM1. Intradermal and subcutaneous administration of this vaccine was previously studied for treatment of colorectal and pancreatic cancer.
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