35 - Golgi complex and endosome antibodies

Abstract

The Golgi complex and endosomes are cytoplasmic organelles involved in the posttranslational modification, processing, and transport of cell surface and intracellular macromolecules. Autoantigens in the Golgi complex include, giantin/macrogolgin, golgin-245, golgin-160, golgin-97, golgin-95/gm130, and golgin-67. Endosome autoantigens include early endosome antigen 1 (EEA1, 162 kDa), cytoplasmic linker protein-170 (CLIP-170, 170 kDa), lysobisphosphatidic acid (LBPA), and glutamate receptor interacting protein (GRIP)-associated protein-1 (GRASP-1). Of interest, all the Golgi complex and endosome autoantigens, with the exception of LBPA, are coiled coil proteins. The significance of this observation is not known except to note that autoantibodies to these coiled coil-rich autoantigens are generally highly specific to each individual autoantigen and do not cross-react with others. A common clinical diagnosis of patients with anti-Golgi antibodies is Sjögren's syndrome, although they are seen in a variety of systemic rheumatic diseases and other conditions. Antibodies to EEA1 were seen in a variety of conditions, including patients with a neurological disease.