349 Functional screening of Cutibacterium acnes isolates reveal determinants of skin inflammation.

Abstract

Cutibacterium acnes (C. acnes) is a ubiquitous commensal bacterium that is generally well tolerated by the human skin immune system. Different strain-types of C. acnes have been reported to be enriched on patients with acne. To understand if these strain-type differences contribute to the develoment of inflammation we generated a library of over 400 C. acnes isolates from skin swabs of healthy and acne subjects and assessed their strain-level identity and inflammatory potential. A higher frequency of phylotype IA-1 C-type strains was observed from acne lesional sites compared to non-lesional sites.