Abstract
To maximize graft-versus-leukemia (GvL) effect while minimizing or avoiding graft-versus-host disease (GvHD) we designed a prospective study of allogeneic PBSC transplantation aimed to achieve a mixed chimerism (MC) status. In order to ensure this objective we combined the use of reduced-intensity conditioning and graft manipulation by means of CD34+ selection. To improve immunological reconstitution early “low dose” (0.5 × 105/Kg CD3+ cells) DLI was scheduled once a month for six months. The PBSC CD34+ selection was performed by CliniMACS device.
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