Abstract
chondrial in situ respiration of the permeabilised ventricular and skeletal (gastrocnemius) muscle fibres was significantly lower in heart failure than in sham preparations by respectively 45% and 20% without ADP and by 20% and 35% with ADP. Perindopril treatment had no effect on these parameters. Similarly, perindopril did not improve alterations in activities of energy metabolism enzymes (creatine kinase, citrate synthase, cytochrome c oxidase, lactate dehydrogenase) either in ventricular or in skeletal muscle. These data suggest that the generalised metabolic myopathy induced by the hemodynamic abnormalities conditioned by the continuous LV overload (aorta clipping) does not result from the increase in angiotensin II level per se. Correction of hemodynamic parameters and LV unloading seem to be a prerequisite for the improvement of muscle energy metabolism abnormalities.
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