Abstract
Background: Skin exposure to ultraviolet radiation causes disruption of fibroblast-extracellular matrix interactions causing loss of/damage to collagen, decreased fibroblast cell density and morphology and degeneration of the elastic fiber network. These result in clinical degenerative changes such as wrinkles, sallow complexion and loss of hydration and elasticity. We developed a photostable, broad-spectrum SPF 30 product with inorganic sunscreen actives and a natural retinol alternative, bakuchiol. Objective: To investigate the effects of a nature-based mineral broad-spectrum sunscreen to improve clinical outcomes of photodamaged skin. Methods: A single-center, open-label study was performed on 49 female subjects aged 35 to 60 years with mild to moderate signs of photodamage. Evaluations of the nature-based sunscreen product were made at baseline and at week 6 after twice daily minimum topical application on the face. The dermatologist investigator and subjects assessed efficacy and tolerability using a 5-point ordinal scale (0 = none, 4 = severe). Noninvasive measurements of skin hydration, barrier function and elasticity were conducted. Results: Investigator clinical evaluations showed significant improvements in skin laxity, fine lines, smoothness, pigmentation, and texture. Subject-rated change from baseline demonstrated similar efficacy as the investigator. Skin hydration significantly improved by 21%. A significant 32% decrease in the retraction time (ms) was measured after 6 weeks of product use, indicating improved skin elasticity. There was no disruption to skin barrier function. No tolerability related issues were observed during study duration. Conclusion: Daily photoprotection using a nature-based broad-spectrum mineral sunscreen containing bakuchiol visibly improved the signs of photodamage and the skin’s biophysical properties.
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