Abstract
OCT, a novel technique for high resolution endoscopic imaging clearly delineates microscopic mucosal and submucosal structures of the GI tract. Aim: To study the ability of OCT to identify and characterize BE. Methods: OCT images were obtained using an endoscopic OCT probe (2.4 mm dia, 0.5 mm focal distance)in patients undergoing surveillance EGD for BE. Images were captured digitally and were objectively rated in terms of clarity, resolution, ease of identification of BE and to determine whether areas of dysplasia could be identified. Four quadrant large particle biopsies were taken from the area of BE at 2 cm intervals and were correlated with OCT images. Results:8 patients with BE (mean age 62.5 years, 6 men) were studied. Mean length of BE was 7.7 (SE 2.2) cms; 3 patients had focal areas of high grade dysplasia. During OCT imaging squamous epithelium and Barrett's epithelium could be readily distinguished. Also, areas with Barrett's epithelium lacked the characteristic thick, dark band which is seen with stratified squamous epithelium. The esophageal mucosa was significantly thicker in the areas of Barrett's epithelium (mean thickness 0.6 mm vs. 0.4 mm, p
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