Abstract
Epithelial barrier integrity is of outermost importance to protect the human body from external harm. One of the key cytokines involved in tissue regeneration is interleukin (IL)-22. During inflammation, IL-22 producing cells are recruited into barrier organs to restore inflammation mediated barrier damage. The aryl hydrocarbon receptor (AhR) has been shown to regulate IL-22 expression in T cells. Previous results from our group indicated that another transcription factor Forkhead box O (FOXO) 4 is expressed in human T cells.
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