(344) - Analysis of the Airways Virome after Lung Transplantation and Its Association with Clinical Outcomes

Abstract

s S135 patients had a favorable outcome after prolonged therapy. 2/6 had positive cultures at the time of the transplant (one despite therapy, one diagnosed at transplant) and both developed early recurrences and died within the first year of transplant. 20 patients developed de novo infections at a median of 15.5 months (0.5-132 months) post LTx. 10/20 did not receive treatment, despite the fact that 7 out of these 10 had some form of radiological abnormalities. 7/10 untreated patients cleared the infection spontaneously. None of the untreated cohort had deaths attributable to MAb infection. Out of the 10 patients who received MAb treatment, 7 died at a median of 41 months (12-83 months) after LTx, with 3 deaths being attributable to MAb infection. There was no relationship found between deaths/attributable deaths and macrolide resistance or rejection therapy. Conclusion: In patients who are infected with MAb pre-LTx, those with positive smear or culture at the time of transplant had poorer outcomes compared to those who had documented negative cultures. Half of the de novo Mab infections post-LTx were not treated without any MAb-attributable adverse outcomes.