34138 Clinical characterization and histopathologic correlation of erythroderma: A retrospective review

Abstract

While the most common causes of erythroderma are benign inflammatory conditions, cutaneous T-cell lymphoma comprises up to 15% of erythroderma cases. Regardless of etiology, individuals with erythroderma may experience significant symptoms of pruritus, cold intolerance, and increased risk of infection. Thus, delay in accurate diagnosis may negatively impact patient outcomes and quality of life. Previous studies have shown that histopathology is nonspecific in up to 50% of skin biopsy specimens in the setting of erythroderma, posing a significant diagnostic challenge.