Abstract
The relationships of serum (Se) to Saliva (Sa) concentrations of Theophylline (Theo) and total methylxanthines (Mx) (Mx = Theo + Caffeine (Caf)) have been established in neonates treated with Theo for apnea (J.Pediatr.96:494,1980). Serum to Sa relationships derived with additional studies have been crossvalidated against the old data. The standard deviations (SD) and correlation coefficients (R) for the Se to Sa relationships are presented below. Data for Mx is presented because of Theo to Caf conversion in neonates. Crossvalidation results indicate that R is high for Mx using both models and for Theo only for the ratio model. The discrepancy between Theo and Mx results may be caused by the wide interindividual differences in conversion from Theo to Caf.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
