340 THE INFLUENCE OF LIFETIME HIP JOINT FORCE ON THE RISK OF SELF-REPORTED HIP OSTEOARTHRITIS: A NEW METHOD TO QUANTIFY PHYSICAL ACTIVITY

Abstract

wear and secondary osteoarthritis. The investigation of this relationship using epidemiologic data can enhance our understanding of the underlying biologic mechanisms which may be at play. We sought to quantify the association between site-specific radiographic osteoarthritis (ROA) and self-reported diabetes. Methods: Site-specific OA status was radiographically-confirmed among subjects drawn from the Clearwater Osteoarthritis Study (COS) (N=3438). The COS is a 25-year longitudinal cohort begun in 1988 to investigate risk factors for the incidence and progression of OA among men and women ages 40 years and older. Biennial physical exams including site-specific radiographs were conducted. The Kellgren & Lawrence ordinal scale was used to determine radiological evidence of the study outcome, ROA. Results: After adjusting for age, gender and body mass index (BMI), subjects who self-reported a history of diabetes were 40% more likely to have hand OA (OR=1.4; 95% C.I. 1.1−1.6; p-value <0.002) than were those without diabetes. Likewise, those subjects with diabetes were 20% more likely to have foot OA, although this was not statistically significant (OR=1.2; 95% C.I. = 0.98−1.5; p-value 0.08).