(340) - Preliminary analysis of PROMIS measures in temporomandibular joint disorder (TMJD)

Abstract

Temporomandibular Joint Disorder (TMJD), a common facial pain condition, is often associated with sleep, fatigue, and psychological disturbances. The recent development of several Patient-Reported Outcomes Measurement Information System (PROMIS) surveys, which has potential widespread application in clinical and research settings, may provide a standardized method to compare different chronic pain disorders. However, no studies have reported outcomes related to PROMIS measures for patients with TMJD. Thus, the current study examined (1) the responses of TMJD patients across several PROMIS measures as compared to normative data and (2) the relationship between these PROMIS measures and the patients' clinical outcomes related to pain and sleep. Data for these TMJD patients (n = 24, mean age 30) was obtained from a larger ongoing study where all participants completed surveys, a sleep assessment, and QST. Preliminary analysis of the PROMIS surveys revealed that the TMJD patients reported anxiety, depression, fatigue, and sleep near to the average of the United States general population (e.g., a T-score of 50 ± 10 SD). Furthermore, while trends were observed with the Widespread Pain Index (WPI) and Graded Chronic Pain Scale (GCPS), higher scores on the Insomnia Sleep Index (ISI) were significantly related to increased scores the PROMIS scales for Sleep Disturbance (r = .47, P = .02) and Impairment (r = .39, P = .05), indicating increased negative outcomes. Additional relationships between the PROMIS measures with other measures of pain and sleep were insignificant or lightly trending, which could be limited by the small sample size. Together, this preliminary data sheds light upon the feasibility of collecting a set of PROMIS surveys in patients with orofacial pain and its relationship with other measures, which may permit comparisons with other chronic pain conditions. Future research should compare PROMIS measures with more symptomatic cohorts (e.g., widespread pain) or cohorts with comorbid sleep and psychological conditions. Supported by NIDCR #R00DE022368.