Abstract
Increased isolation of R-Sp have significant implications. To determine changing patterns of Sp susceptibility, all Sp isolated from 1988 to 1993 were tested. Penicillin susceptibility was defined by MICs: Sensitive (S) <0.1 ug/ml. Relatively Resistant (RR) 0.1 to 1 ug/ml and Highly Resistant (HR) >1 ug/ml. Results are shown in the table: 584 Sp were isolated, 499(85.4%) S and 85(14.6%) R (66 [11.3%] RR and 19[3.3%] HR. An increase of 8 fold occured in RR-sp in 1989 and a 1.75 fold in 1990. No significant increase in HR-Sp occured in first 5 years of the study; in 1993 there was a >100% increase. Our data suggest that empiric management of serious Sp infections should include antimicrobials effective against R-Sp. This is important since Sp is a major causes of childhood meningitis.
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