Abstract
The largest ever statistical study of the genetics of type 1 diabetes has been funded by the Wellcome Trust (London, UK) and the Juvenile Diabetes Research Foundation. Over the course of five years, a $34 (£20) million grant will be used to identify the genes involved in juvenile onset (insulin dependent) diabetes, using 10 000 diabetic and 10 000 healthy subjects. The research, which will be based at the Wellcome Trust Centre for Molecular Mechanisms in Disease (University of Cambridge, UK), will also incorporate analysis of non-obese diabetic (NOD) mice. This follows on from a recently published Korean–Canadian study, in which juvenile diabetes was eliminated in NOD mice by insulin gene therapy. Ahyun Chul Lee and colleagues (Yonsei University Medical School, Seoul, South Korea) used a recombinant adeno-associated virus that expressed an insulin analogue, and prompted long-term remission from diabetes. These data hold great promise for treatment in humans, which currently requires several insulin injections per day. AR
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