Abstract
The human placenta has long been recognized as an organ of hormogenesis. Various in-vitro and in-vivo experiments have demonstrated the biosynthesis of hormones by the placenta, e.g., HCG, HPL, estrogen, progesterone, releasing hormones, endorphins, etc. Most of these studies were done either on animal models or by perfusion of single cotyledon of a placenta. In this study, whole term placentas were perfused immediately after delivery with packed red cells suspended in Hank's solution using the apparatus designed by Krantz and Panos. The pH, pO2, PCO2, glucose utilization and lactic acid production were monitored at regular intervals throughout the study period to establish the prevailing physiologic conditions. The glucose utilization and lactic acid production increased significantly during the course of perfusion indicating the viability of the placenta (fig.1) During the experiment pH, PO2, PCO2 were maintained within physiological limits by disc oxygenator. This model of perfusion of whole placenta appears to be useful for studying the regulation of hormone synthesis & metabolism of drugs by the placenta.
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