Abstract
Biological differences in sensory processing between human and model organisms may present significant obstacles to translational approaches in treating chronic pain. Such obstacles may include functional differences in target receptor pharmacology and signaling or fundamental differences in neuronal physiology. While cultures of rodent dorsal root ganglion (rDRG) neurons have proven useful for identifying new analgesic targets and elucidating signaling pathways, notable translational failures have recently raised questions about the wisdom of developing drugs for pain relief in rodents for eventual use in humans.
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