Abstract
Abstract Background Chat Generative Pre-training Transformer (ChatGPT) is a popular artificial intelligence-based chatbot that rapidly provides responses to online inquiries. As a language-processing – rather than a scientific – tool, ChatGPT does not guarantee accuracy. The United States Food and Drug Administration (FDA) labels medications with significant risk of serious or life-threatening adverse effects with boxed warnings (BW). We sought to assess the accuracy of ChatGPT regarding FDA BW for antibiotics. Methods FDA labels for commonly-used antibiotics were categorized through the DailyMed database of the National Library of Medicine (Table 1). ChatGPT-3.5 was then queried regarding FDA BWs using the following query: “Are there any boxed warnings on the FDA label for XX [medication] and if so, what are they?” Responses were sorted into 3 categories:(1) “Matching”: ChatGPT accurately reported both existence and content of BW or its absence;(2) “Inaccurate”: ChatGPT accurately reported a BW but erred on some aspects of the content; and(3) “Incorrect”: ChatGPT misidentified existence of BW, or listed incorrect adverse effects (AE)Table 1:FDA Boxed Warnings for Commonly Used Antibiotics Results Of the 41 antibiotics queried, 9 have FDA BWs and ChatGPT correctly identified the existence of all 9. However, ChatGPT correctly matched the AE of the FDA BW in only 3 instances (33%); in five instances (56%), ChatGPT listed inaccurate AEs (either under- or overinclusive) and in one (11%), ChatGPT listed an incorrect AE. For the 32 antibiotics without an FDA BW, ChatGPT reported that 23 (72%) had a BW (Figure 1). Figure 2 provides some examples of incorrect ChatGPT claims regarding AEs.Figure 1:ChatGPT Responses about FDA Boxed WarningsFigure 2:Examples of Incorrect ChatGPT claims Conclusion ChatGPT reported inaccurate and incorrect information about FDA BW for antibiotics. Clinicians should be aware of this new source of information for patients. Disclosures All Authors: No reported disclosures
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