Abstract
Bitter taste is mediated by bitter taste receptors (T2Rs), a multigene family of G-protein-coupled receptors on the tongue. 25 different T2Rs are known to be expressed. T2Rs have recently been found in several regions of the body, and T2R38 has been reported to be expressed on lymphocytes in peripheral blood. Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, and skin-infiltrating T cells play a pivotal role in the development and maintenance of AD. C-C chemokine receptor type4 (CCR4) and type10 (CCR10) are selectively expressed on skin lymphocytes and are important GPCRs that positively regulate the lymphocytes homing to the skin.
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