Abstract
Introduction: Cutibacterium acnes, the main bacterial species of the pilosebaceous unit, plays a major role in acne. Recent papers demonstrated that specific C acnes phylotypes were correlated with the severity of inflammatory acne and reported a specific loss of C acnes phylotype diversity in this context. Objectives: The aim of the study was to evaluate the efficacy of a new dermocosmetic product containing Myrtus communis and Celastrol-enriched plant cell culture extracts on C acnes phylotype abundance and clinical parameters in subjects with mild to moderate acne vulgaris. Materials/methods: Efficacy on C. acnes phylotype diversity was evaluated by single-locus sequence typing sequencing after 57 days of twice daily application of the product. Clinical parameters of acne and product tolerance were also assessed. Results: Our study confirmed the link between the presence of some C. acnes phylotypes and acne. At day 57, the product had a positive impact on C. acnes phylotypes: a significant decrease of propathogen phylotype IC and increased of nonpathogen phylotype IB were observed. In parallel, the clinicals results showed a significant decrease of inflammatory and total acne lesions, and a significant improvement of global acne evaluation score. The tolerance of the product was assessed very good. Conclusion: This study showed the topic modulation of C. acnes phylotype diversity by this new dermocosmetic product containing Myrtus communis and Celastrol enriched plant cell culture extracts associated with a significant clinical efficacy.
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