Abstract
Abstract Background and Aims During the COVID-19 pandemic many facets of our lives were affected, including the healthcare systems worldwide. We aimed to assess the hospitalization rates of hemodialysis (HD) patients with confirmed COVID-19 infection (COVID-19+) versus other patients (i.e., patients with no documented COVID-19 infection in the European Clinical Database (EuCliD®)) in 2020 and their relation to HD patients from the pre-pandemic era in 2019. Method We included 63,216 HD patients treated in 2019-2020 in NephroCare centers from 23 countries from EuCliD® in the Europe, Middle East, and Africa (EMEA) region. Monthly hospitalization rates (hospital admission per 10,000 patients) were estimated separately for COVID-19+ and other HD patients in 2020, and HD patients treated in 2019, with COVID-19+ status as a time-varying variable. The number of COVID-19 cases and deaths were extracted from data released by the European Commission Joint Research Centre (ECJRC)[1]. The correlation between the monthly hospitalization rates and numbers of COVID-19 cases and deaths in general population (GP) were evaluated. Results Characteristics of the approximately 42,000-43,000 monthly treated HD patients were comparable between 2019 and 2020 (Table 1). The hospitalization rates were much higher for COVID-19+ HD patients throughout 2020 compared to other HD patients in 2020 and HD patients in 2019. The hospitalization rates were highest in the spring of 2020 for COVID-19+ HD patients. However, in 2020 other HD patients’ hospitalization rates were lower than the 2019 HD patients’ hospitalization rates. Interestingly the hospitalization rates of other HD patients in 2020 dipped even more below hospitalizations for HD patients in 2019 following the GP pandemic waves (Figure 1). Hospital admission for both COVID-19+ and other HD patients were inversely correlation with the pandemic conditions in GP (Figure 2; spearman correlation coefficients [ρ] with COVID-19 cases/deaths in GP, -0.77/-0.22 and -0.29/-0.64, respectively, for COVID-19+ and other HD patients). Conclusion Our study indicated the COVID-19 pandemic had an impact on hospitalization rates of both HD patients with a COVID-19 diagnosis and those patients without a documented COVID-19 infection. Potential reasons of decreased hospitalization rates in patients without a documented COVID-19 diagnosis could be healthcare resource constraints or regarding patient concerns about exposure to COVID-19 in hospital settings [2].
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