335. Cardiovascular risk after hypertensive disorders of pregnancy in women with and without inheritable thrombophilia, preliminary results

Abstract

Introduction Women who develop hypertensive disorders of pregnancy (HD) are at increased risk for cardiovascular disease later in life. Presence of inheritable thrombophilia is associated with poor placentation in HD. It is unknown whether the combination of inheritable thrombophilia and early-onset HD (HD Objective To compare cardiovascular risk factors 12.5 years in women after early-onset HD with and without inheritable thrombophilia. Methods We compared two prospective cohorts of women with a history of early-onset of HD. Women with inheritable thrombophilia (protein C deficiency, protein S deficiency, heterozygous factor V Leiden mutation and heterozygous prothrombin gene G20210A mutation) were compared to women without thrombophilia. Women with pre-existing hypertension were excluded. Physical examination was performed and cardiovascular parameters in serum were measured. Results Sixteen women with inheritable thrombophilia and 98 without thrombophilia were included. Seventy-five percent of all women developed one or more cardiovascular risk factor(s). Hypertension was present in 31.3% of women with thrombophilia and 33.7% without (p = 1.000), increased body mass index >25 kg/m[b] in 43.8% with thrombophilia and 53.1% without (p = 0.593) and hypercholesterolemia in 31.3% with thrombophilia and 43.9% without (p = 0.420). Differences were not significant. Discussion Our preliminary findings demonstrated similar cardiovascular risk factors in women after early-onset HD with and without inheritable thrombophilia. It raises the question whether there is a difference between the pathophysiological origin of HD between women with and without thrombophilia. In general, the role of thrombophilia in the development of cardiovascular risk factors is unclear. However, in this subgroup of women with a history of early-onset HD, thrombophilia does not modify the development of cardiovascular risk factors.