Abstract
Impaired stem cell functions, which gradually fail to replenish damaged and senescent cells in distinct organ parenchyma can lead to tissue atrophy and organ aging. This failure can either be due to an intrinsic dysfunction of stem/progenitor cells, the disruption of the corresponding stem cell niche, or a combination of both. Fibroblasts in the connective tissue region of many organs, such as skin, contribute to the formation of stem cell niche. Though the impact of the connective tissue resident fibroblasts on stem cell niches and organ aging is an emerging concept, the underlying mechanisms are largely unexplored.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
