Abstract
Palmoplantar psoriasis is related to a significantly decreased quality of life compared with generalized psoriasis. However, therapeutic guidelines for palmoplantar psoriasis have not been established due to limited data. Topical treatment is typically the first-line recommendation, but it is often ineffective in palmoplantar psoriasis, as standard preparations do not adequately penetrate the thickened stratum corneum of the palms and soles. A novel polymeric emulsion lotion with a fixed combination of corticosteroid halobetasol propionate 0.01% and retinoid tazarotene 0.045% (HP/TAZ) may overcome this challenge, as it has demonstrated increased dermal penetration compared with conventional preparations of either ingredient.
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