33327 A case of reed syndrome with an unusually extensive cutaneous burden

Abstract

Reed Syndrome, or hereditary leiomyomatosis and renal cell carcinoma syndrome, is a rare, autosomal dominant genetic condition that predisposes individuals to a triad of cutaneous leiomyomas (CLMs), uterine leiomyomas and renal cell carcinoma. CLMs are often the first manifestation of the syndrome, occurring in 76% of patients typically in their second to fourth decade of life. CLMs are smooth-surfaced, reddish-brown papules or nodules that range 0.2 to 2.0 cm in diameter and average 25 in number. We present a case of a 47-year-old female with Reed syndrome with an unusually extensive cutaneous burden, with a total of 361 cutaneous lesions, far above the average reported number of 25. Due to the extent of her cutaneous burden, painful nature of the lesions and failure to respond to standard therapies, she was referred for fully ablative erbium laser resurfacing therapy. The use of fully ablative erbium laser resurfacing therapy for treatment of CLMs has not been reported in the literature to date. One year following laser therapy, the treatment area not only healed with normal repigmentation, but there was also no evidence of CLMs recurrence. Given the effectiveness of this unique therapy, fully ablative erbium laser resurfacing should be kept in mind as a treatment option for both cosmetic and symptomatic CLMs.