Abstract
Abstract Prostaglandin synthesis from arachidonic acid by dog renal microsomes was studied. Formed prostaglandin and thromboxane were identified and quantified by thin layer radiochromatography and thin layer immunochromatography. Inner medullary microsomes formed predominantly 6-keto PGF1α at a low substrate/enzyme ratio, whereas 6-keto PGF1α and PGF2α were the major products at a high substrate/enzyme ratio. On the other hand, cortical microsomes formed predominantly 6-keto PGF1α at both high and low substrate/enzyme ratio, followed quantitatively by PGF2α formation.
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