33288 Hidradenitis suppurativa and dermatologic comorbidities in adults: A national-cross sectional study

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Hidradenitis suppurativa (HS) is a rare chronic, inflammatory condition characterized by the development of painful sinus tracts and is associated with numerous comorbidities. Several studies demonstrate an association of HS with pyoderma gangrenosum and acne conglobata, but there has been no broad-spectrum investigation into the dermatologic comorbidities associated with HS using nationally representative data. We analyzed the 2016-2018 National Inpatient Sample, a cross-sectional sample of 20% of all U.S. hospitalizations, for adult patients with and without HS. Compared with the general inpatient population, associations of HS with 25 dermatologic conditions were determined using multivariable logistic regression, adjusting for age, race, sex, and insurance type. Overall, 90,879,561 total hospitalizations were identified, with 62,785 having a diagnosis of HS. As seen previously, HS was more likely to affect females and Black patients. The prevalence of having any of the 25 dermatologic conditions was higher in patients with HS (24.60%, 95% confidence interval [CI]: 23.82%-25.42%) than without (5.30%, 95% CI: 5.26%-5.33%). In multivariable logistic regression models controlling for age, sex, race, and insurance type, HS was associated with having any dermatologic condition (adjusted odds ratio 7.17, 95% CI: 6.86-7.50). Specifically, HS was associated with 18 of the 25 dermatologic conditions. Our research highlights the association between HS and several dermatologic conditions not previously reported. While this study validates the complexity of the HS disease process, more research into HS pathology and etiology is strongly warranted.