Abstract
Antimicrobial peptides (AMPs) are part of the skin’s innate immune system and help protect from infections. 12-hydroxystearic acid (12HSA) is a well-known cosmetic ingredient used for skin appearance and barrier-building benefits. It is believed that 12HSA deposited through cosmetic formulations could provide long-lasting protection against pathogenic microbes by modulating the skin’s innate immune response. The objective of this research was to investigate if a handwash containing 12HSA could provide enhanced protection against a test microbe in vivo, through increased AMP secretion as measured from skin cells in vitro and ex vivo.
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