331 Characterisation of interfollicular stem cells and early TA cells during the transition from infant to child skin

Abstract

In the interfollicular epidermis, self-renewing stem cells (KSC) generate a short-lived population of transit amplifying (TA) cells that undergo terminal differentiation after a number of cell divisions. Here, we isolated KSC and highly proliferative early TA cells, based on their capacity to adhere to type IV collagen. Because in infancy epidermis appears to be immature and the barrier not fully protective, this work aims to characterize KSC and early TA cells during transition from infant to child in term of differentiation, stemness, proliferation and regenerative capacity.