Abstract
Hepatocyte transplantation (HT) is being explored as an alternative to orthotopic liver transplantation. Currently, invasive needle biopsies are the only method to assess donor cells in the host liver. The engraftment, survival, proliferation and immune rejection of donor cells are difficult to monitor with needle biopsies because of the spatial heterogeneity of liver repopulation by transplanted cells. Koretsky described models in which ectopic expression of (CK) in liver allows 31P magnetic resonance spectroscopy (MRS) measurements of phosphocreatine (PCr), a metabolite not normally produced in liver (1).
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