33.3 Effects of Adversity on Trajectories of Substance Use Disorder Development in Drug-Naïve Youth With Family Loading for Substance Use Disorder

Abstract

The impact of social adversity on brain plasticity and physiology is posited, albeit with limited evidence, as a potential risk factor for the development of substance use disorders (SUD). Neuroimaging research has linked not only parental education and income to morphological brain abnormalities but also abnormal reward processing to family history (FH) and the development of SUD in adolescents. However, because not all individuals with FH for SUD go on to develop SUD, it is imperative to identify the ones that are at high risk (HR) for SUD, which could be related to possible unique interactions of social adversity and predisposing brain states conferred by FH.