Abstract
Palmoplantar pustulosis (PPP) is a chronic inflammatory disease characterized by sterile pustules on the palms and soles, and has an impact on patient quality of life. Spesolimab is a first-in-class humanized anti-interleukin 36 receptor monoclonal IgG antibody, previously investigated in a phase IIa PPP trial. In this phase IIb trial (NCT04015518), patients with moderate-to-severe PPP were assigned to 1 of 5 groups; they received a total subcutaneous loading dose of 1500/3000 mg spesolimab or placebo for the first 4 weeks followed by 300/600 mg spesolimab or placebo q4w.
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