Abstract
Introduction Studies have reported an association between umbilical cord blood levels of PlGF (placental growth factor) and soluble fms-tyrosine kinase-1 (sFlt-1) and neonatal complications, including bronchopulmonary dysplasia (BPD). Objective To determine whether maternal serum levels of sFlt-1, PlGF and their ratio in women with suspected or with confirmed preeclampsia are associated with the development of BPD and other neonatal complications, independent of gestational age in preterm neonates. Methods In patients submitted with suspected or clinically confirmed preeclampsia maternal blood was sampled for determination of serum levels of sFlt-1, PlGF and their ratio. Women with singleton pregnancies, delivering before 34 weeks of gestation were included. Fetal/neonatal outcomes were death, SGA (birthweight Results A total of 143 singleton deliveries were analyzed. The median GA was 28.2 weeks (range 20.0–33.6) at study entry and 29.2 weeks (20.6–34.0) at delivery. Fetal/neonatal death occurred in 17, birthweight Conclusions There is no direct connection between the biomarkers and adverse neonatal outcomes. Maternal PlGF and sFlt- 1/PlGF-ratio are predictors of prematurity, and therefore indirectly related to complications such as BPD, RDS and SGA.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
