Abstract
In chronic inflammatory skin diseases (CISD), different transcription factors have emerged as crucial players in the pathogenesis. The CCAAT/enhancer-binding protein beta (CEBPB) is a well-known transcription factor sensitive to various immunogenic stimuli. In this study, we investigate CEBPB in Keratinocytes and aim at dissecting its functional role in skin inflammation. Using a computational approach combining transcriptomics with deep clinical phenotyping of CISD patients, we identified CEBPB as novel factor associated with skin inflammation.
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