Abstract
Background: Sortilin (SORT1), or neurotensin receptor-3, is a scavenging receptor in the Vacuolar Protein Sorting 10 protein (Vps10p) family. SORT1 is involved in the internalization and trafficking of its ligands through an endocytic process and is reported to play a role in cancer cell survival and progression, making SORT1 a candidate for novel drug delivery. The pattern and prevalence of SORT1 expression in different healthy and cancer tissues is still not well understood.
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