Abstract
Background: Angiogenesis is crucial for growth of all tumors, and mature and immature endothelial cells, such as circulating endothelial cells (CECs) and endothelial progenitor cells, are present in the human blood. Vasculogenesis is not restricted to embryonic development, and there are putative circulating endothelial progenitors which can participate in the generation of new vessels. CECs are extremely rare in normal peripheral blood, but it has been shown that their number is significantly increased in many pathological conditions, including cancer.
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