Abstract
most sensitive (p < 0.001 between % changes) of 5 blood tests for detecting fibrosis progression (0.25±0.29 at baseline vs 0.31±0.32 at 2 years, p = 0.003). CM was also reproducible (ric = 0.815). The % change in CM was significantly (p = 0.039) higher (median:32.3%) than that of area of fibrosis (median: 19.9%), which was the histological characteristic having the most significant change but poorly reproducible (ric = 0.439). Conclusion: For the diagnosis of cirrhosis, a specific test is more appropriate than a standard fibrosis test. A specific test offers the advantages of a high correct classification rate and excellent dynamic sensitivity and reproducibility. Its detailed classification (6 classes) also offers precise diagnostic probability. Thus, the CM test, with its specific classification, offers a more exact diagnostic method adapted to clinical practice.
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