32304 Risk of skin cancer in sexual minority patients compared with heterosexual patients: A retrospective cohort study

Abstract

Data on risk of basal cell carcinoma (BCC), squamous cell carcinoma and squamous cell carcinoma in situ (SSC/SCCIS), malignant melanoma and melanoma in situ (MM/MIS) in men who have sex with men (MSM) and females who have sex with females (FSF) are limited. We conducted a retrospective cohort study at a community health center between August 2014-August 2020. Cancer outcomes were identified via International Statistical Classification of Diseases, 9th/10th Revisions, Clinical-Modification codes. Adjusted risk ratios (aRRs) and 95% confidence intervals (CIs) were calculated using log binomial regression and adjusted for age and HIV status. Models for risk in FSF were conducted among HIV-negative patients and adjusted for age due to sample size. Our study included 25,594 cisgender males, 16,961 cisgender females, of whom 56.06% were MSM and 21.56% were FSF. When compared with the heterosexual group, there was a significant difference in risk of BCC in MSM (aRR: 2.62 (95% CI 1.7-4.03) and no significant difference in FSF (aRR: 1.02 (95% CI 0.46-2.3). There was a significant difference in risk of SCC/SCCIS in MSM (aRR: 7.65 (95% CI 2.4-24.3) and no significant difference between FSF (aRR: 1.52 (95% CI 0.55-4.2). There was no significant difference in the risk of MM/MIS in MSM (aRR: 1.42 (95% CI 0.84-2.4) or FSF (aRR: 1.02 (95% CI 0.51-2.06) when compared with heterosexual patients. Our findings are consistent with prior studies based on self-report that have shown a higher risk of NMSC among MSM. The risk of SCC among MSM may be particularly increased.