Abstract
A number of tetracycline-regulated systems constructed in rAAV vectors were evaluated to control in vivo expression of glial cell line- derived neurotrophic factor (GDNF) in the rat neostriatum. The first system involved two vectors: rAAV construct contained tetracycline (tet) -inducible promoter driving expression of GDNF (tet-GDNF), and the other was a bicistronic vector encoding the reverse transactivator and silencer for the tet-regulated system (rtTA/ tTS). The second vector system incorporated all the elements required for the regulated expression of GDNF in one construct.
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