322P Rapid genetic screening experience among endometrial cancer about Lynch syndrome by surgeon

Abstract

Background Lynchsyndromeincreaseriskofmostlyendometrialcancerand colorectal cancer. There is not much study about detecting algorithm among Korean population by gynecologic oncology surgeon. We undertook this study to investigate this. Methods Aretrospectivereviewofendometrialcancerpatientswhowascounseled about Lynch syndrome in Department ofObstetrics and gynecology, Samsung Changwon Hospital by single surgeon was done. Clinical information was extracted from the medical record including age, family and personal history ofcancer, immunohistochemistry(IHC),microsatelliteinstabilitytest(MSI),andgenesequencing results. Risk management and posttest education after result were offered about risk reducing options and cascade testing for affected individual Results Total test was 16.There were two germline mutations (both MSH2) (c.23C>T (p.Thr8Met),c.187delG(p.Val63*).BothwerenegativeforMSH2IHC,Butnopatient matched criteria ofAmsterdam. Four variation ofunknown significance (VUS) was found (Three MSH2 and One MLH1).Among those all were abnormal in IHC and there was only one Amsterdam criteria matched patient. There were two unstable MSI patients, one was MSH2 germline mutation and the other was MSH2 VUS. Median age was 57(41 ~76).Most caseswere endometrioidtype (11/16,69%).Seventyfivepercent were stage I(12/16). Conclusions We found two MSH2 germline mutation patients among this population. Gynecologic oncology surgeon can be adapted to develop the ability to assess and evaluate genetic risk among endometrial cancer. Legal entity responsible for the study N/A Funding N/A Disclosure All authors have declared no conflicts of interest.