322 Type 2 cytokines regulate dermal adipocyte function early in life through hormone-sensitive lipase

Abstract

Type 2 immune responses have been increasingly linked with tissue maintenance, regeneration and metabolic homeostasis. The molecular basis of regulator and effector mechanisms of type 2 immunity in skin regeneration and homeostasis, particularly of the dermal white adipose tissue (dWAT), is still lacking. Here, we demonstrate that the type 2 cytokines IL-4/IL-13 are critical regulators of dWAT homeostasis and function in early life. To decipher the role of type 2 signals in skin regenerative processes, we systematically analyzed postnatal hair cycling and hair cycling-associated changes of the dWAT in back skin of mice with global deficiency of IL-4Ra signaling.