3.22 Carbonylation and Decarbonylation Reactions

Abstract

Introduction of carbon monoxide into organic molecules is intrinsically important in synthetic organic chemistry in both laboratory and industrial scale. A number of transition metal-catalyzed carbonylation reactions have been developed to prepare a wide range of carbonyl compounds. Radical carbonylation reactions have emerged as a useful tool for carbonylation of alkyl moieties, since the radical process can obviate the use of rather labile alkyl metal bonds. This chapter presents important recent advances in carbonylation chemistry. The chapter also focuses on decarbonylation reactions, including decarbonylative coupling reactions, which are also useful in organic synthesis.