Abstract
Among allergic diseases, atopic dermatitis, asthma, hay fever, and urticarial have achieved excellent results for the development of biologics such as omalizumab and dupilumab. The scientific basis for disease and biologics is often supported by disease gene cohort studies centered on genome-wide association studies (GWASes). Immunoglobulin E (IgE), which is produced mainly in plasma cells, plays a crucial role in immune functions and is related to Th2 cell-mediated allergic inflammatory diseases such as atopic dermatitis, asthma, and allergic rhinitis.
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