32 - Salmonella Infections

Abstract

Member of the bacterial genus Salmonella cause a wide range of disease in mammals, but broad cause typhoidal and non-typhoidal disease in humans. Typhoid is an invasive disease and cause by specific serovars (S. Typhi and S. Paratyphi A pathovars). Non-typhoidal disease is associated with enterocolitis and diarrheal. We have new conjugate vaccines for preventing disease caused by S. Typhi, but we lack vaccines against other Salmonellae. Antimicrobials remain the key mechanism for disease treatment and control, but resistance to antimicrobials is problematic and increasing.