Abstract
Paraoxonase-1 (PON1) is a cardio-protective enzyme associated with plasma high-density lipoprotein (HDL). In this study we investigated effects of HOBr, a pro-inflammatory mediator, on plasma PON1 activity. In initial studies, HOBr or HOCl was added to 5-fold diluted human plasma and PON1 phosphotriesterase activity was assayed. Consistent with prior reports, addition of HOCl (2000 uM) to plasma caused loss of PON1 activity, which declined to 71 ± 3 % normal (P 0.05). In conclusion, our results demonstrate HOBr and brominated amines, such as taurine may be important mediators of PON1 activity during inflammation. Supported by Midwestern University.
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